Article

Elevated levels of iodide promote peroxidase-mediated protein iodination and inhibit protein chlorination

2024-02-23

Abstract excerpt

At inflammatory sites, immune cells generate oxidants including H₂O₂. Myeloperoxidase (MPO), released by activated leukocytes employs H₂O₂ and halide/pseudohalides to form hypohalous acids that mediate pathogen killing. Hypochlorous acid (HOCl) is a major species formed. Excessive or misplaced HOCl formation damages host tissues with this linked to multiple inflammatory diseases. Previously ( Redox Biology , 2020...

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Literature Corpus work: 48b1a697-b5de-5650-a6c7-d93a50dcbdfe
DOI: 10.1101/2024.02.23.581700

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