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Article

Novel intra- and inter-molecular sulfinamide bonds in S100A8 produced by hypochlorite oxidation.

The Journal of biological chemistry - 7 Sept 2001

Raftery M J, Yang Z, Valenzuela S M, Geczy C L

Abstract excerpt

Hypochlorite is a major oxidant generated when neutrophils and macrophages are activated at inflammatory sites, such as in atherosclerotic lesions. Murine S100A8 (A8) is a major cytoplasmic protein in neutrophils and is secreted by macrophages in response to inflammatory stimuli. After incubation with reagent HOCl for 10 min, approximately 85% of A8 was converted to 4 oxidation products, with electrospay...

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Identifiers

PMID: 11445563
DOI: 10.1074/jbc.M101566200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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