Article
Myeloperoxidase generates 5-chlorouracil in human atherosclerotic tissue: a potential pathway for somatic mutagenesis by macrophages.
The Journal of biological chemistry - 10 Feb 2006
Takeshita Junko, Byun Jaeman, Nhan Thomas Q, Pritchard David K, Pennathur Subramaniam, Schwartz Steven M, Chait Alan, Heinecke Jay W
Abstract excerpt
Somatic mutations induced by oxidative damage of DNA might play important roles in atherogenesis. However, the underlying mechanisms remain poorly understood. Myeloperoxidase, a heme protein expressed by select populations of artery wall macrophages, initiates one potentially mutagenic pathway by generating hypochlorous acid. This potent chlorinating agent reacts rapidly with primary amines to yield long-lived,...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.