Article
Mice deficient in the alpha subunit of G(z) show changes in pre-pulse inhibition, anxiety and responses to 5-HT(1A) receptor stimulation, which are strongly dependent on the genetic background.
Psychopharmacology - 1 Dec 2007
van den Buuse Maarten, Martin Sally, Holgate Joan, Matthaei Klaus, Hendry Ian
Abstract excerpt
RATIONALE: G(z), a member of the G(i) G protein family, is involved in the coupling of dopaminergic and serotonergic receptors. In the present study, we investigated behaviour of mice deficient in the alpha subunit of G(z) and focused on pre-pulse inhibition (PPI) and anxiety-like responses and the role of serotonin-1A (5-HT(1A)) receptors. MATERIALS AND METHODS: We compared male and female wild-type and...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.