Article
Impaired olfactory behavior in mice deficient in the alpha subunit of G(o).
Brain research - 21 Jun 2002
Luo Alice H, Cannon Eliot H, Wekesa Kennedy S, Lyman Richard F, Vandenbergh John G, Anholt Robert R H
Abstract excerpt
The ability to respond to chemical signals is essential for the survival and reproduction of most organisms. Olfactory signaling involves odorant receptor-mediated activation of G(olf), a homologue of G(s), on the dendrites of olfactory neurons. Olfactory receptor cells, however, also express Galpha(i2) and Galpha(o) on their axons, with all neurons expressing G(o) and a subset G(i2). Despite their abundance,...
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