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Article

Sex-dependent behavioral functions of the Purkinje cell-specific Gαi/o binding protein, Pcp2(L7).

Cerebellum (London, England) - 1 Dec 2012

Walton James C, Schilling Karl, Nelson Randy J, Oberdick John

Abstract excerpt

We previously reported motor and non-motor enhancements in a mouse mutant with an inactivated Purkinje cell-specific gene, Pcp2(L7), that encodes a GoLoco domain-containing modulator of Gi/o protein-coupled receptors. Effects included elevated learning asymptote with repeated rotarod training, increased acquisition rate in tone-cued fear conditioning (FC), and subtle male-specific changes in both acoustic startle...

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Identifiers

PMID: 22528962
DOI: 10.1007/s12311-012-0368-4
PMCID: PMC5438593

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