Article
Genetic analysis of the dihydrofolate reductase-thymidylate synthase gene from geographically diverse isolates of Plasmodium malariae.
Antimicrobial agents and chemotherapy - 1 Oct 2007
Tanomsing Naowarat, Imwong Mallika, Pukrittayakamee Sasithon, Chotivanich Kesinee, Looareesuwan Sornchai, Mayxay Mayfong, Dolecek Christiane, Hien Tran Tinh, do Rosario Virgilio E, Arez Ana Paula, Michon Pascal, Snounou Georges, White Nicholas J, Day Nicholas P J
Abstract excerpt
Plasmodium malariae, the parasite responsible for quartan malaria, is transmitted in most areas of malaria endemicity and is associated with significant morbidity. The sequence of the gene coding for the enzyme dihydrofolate reductase-thymidylate synthase (DHFR-TS) was obtained from field isolates of P. malariae and from the closely related simian parasite Plasmodium brasilianum. The two sequences were nearly...
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