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Article

Rare, highly pyrimethamine-resistant alleles of the Plasmodium falciparum dihydrofolate reductase gene from 5 African sites.

The Journal of infectious diseases - 15 Nov 2004

Bates Sarah J, Winstanley Peter A, Watkins William M, Alloueche Ali, Bwika Juma, Happi T Christian, Kremsner Peter G, Kublin James G, Premji Zul, Sibley Carol Hopkins

Abstract excerpt

In eastern and southern Africa, there has been a rapid increase in the prevalence of alleles with mutations in the Plasmodium falciparum dihydrofolate reductase gene (dhfr) associated with increased risk of clinical failure of sulfadoxine-pyrimethamine (S/P). Molecular methods for surveillance of...

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PMID: 15499534
DOI: 10.1086/425078

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-15499534-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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