Article
Resistance to antifolates in Plasmodium falciparum monitored by sequence analysis of dihydropteroate synthetase and dihydrofolate reductase alleles in a large number of field samples of diverse origins.
Molecular and biochemical parasitology - 1 Nov 1997
Wang P, Lee C S, Bayoumi R, Djimde A, Doumbo O, Swedberg G, Dao L D, Mshinda H, Tanner M, Watkins W M, Sims P F, Hyde J E
Abstract excerpt
Resistance of Plasmodium falciparum to antifolate chemotherapy is a significant problem where combinations such as Fansidar (pyrimethamine-sulfadoxine; PYR-SDX) are used in the treatment of chloroquine-resistant malaria. Antifolate resistance has been associated with variant sequences of dihydrofolate reductase (DHFR) and dihydropteroate synthetase (DHPS), the targets of PYR and SDX respectively. However, while...
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