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Article

PPARgamma activation primes human monocytes into alternative M2 macrophages with anti-inflammatory properties.

Cell metabolism - 1 Aug 2007

Bouhlel M Amine, Derudas Bruno, Rigamonti Elena, Dièvart Rébecca, Brozek John, Haulon Stéphan, Zawadzki Christophe, Jude Brigitte, Torpier Gérard, Marx Nikolaus, Staels Bart, Chinetti-Gbaguidi Giulia

Abstract excerpt

Th1 cytokines promote monocyte differentiation into proatherogenic M1 macrophages, while Th2 cytokines lead to an "alternative" anti-inflammatory M2 macrophage phenotype. Here we show that in human atherosclerotic lesions, the expression of M2 markers and PPARgamma, a nuclear receptor controlling macrophage inflammation, correlate positively. Moreover, PPARgamma activation primes primary human monocytes into M2...

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Identifiers

PMID: 17681149
DOI: 10.1016/j.cmet.2007.06.010

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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