Article
Pro-inflammatory monocyte-macrophage polarization imbalance in human hypercholesterolemia and atherosclerosis.
Atherosclerosis - 1 Dec 2014
Fadini Gian Paolo, Simoni Francesco, Cappellari Roberta, Vitturi Nicola, Galasso Silvia, Vigili de Kreutzenberg Saula, Previato Lorenzo, Avogaro Angelo
Abstract excerpt
Monocyte-macrophages (MoMas) play a major role in atherosclerosis. In mice, hypercholesterolemia increases pro-inflammatory monocytes that promote plaque growth, but whether this is true also in humans in unknown. We herein analyzed monocyte subsets and MoMa phenotypes in familiar (FH, n = 22) and non-familiar (NFH, n = 20) hypercholesterolemic compared with normocholesterolemic (CTRL, n = 20) patients. We found...
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