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Article

Combined effects of thrombosis pathway gene variants predict cardiovascular events.

PLoS genetics - 1 Jul 2007

Auro Kirsi, Alanne Mervi, Kristiansson Kati, Silander Kaisa, Kuulasmaa Kari, Salomaa Veikko, Peltonen Leena, Perola Markus

Abstract excerpt

The genetic background of complex diseases is proposed to consist of several low-penetrance risk loci. Addressing this complexity likely requires both large sample size and simultaneous analysis of different predisposing variants. We investigated the role of four thrombosis genes: coagulation factor V (F5), intercellular adhesion molecule 1 (ICAM1), protein C (PROC), and thrombomodulin (THBD) in cardiovascular...

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Identifiers

PMID: 17677000
DOI: 10.1371/journal.pgen.0030120
PMCID: PMC1934395

Genes

PROC
ICAM1
THBD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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