Shared and Distinct Genomics of Chronic Thromboembolic Pulmonary Hypertension and Pulmonary Embolism.

doi:10.1164/rccm.202307-1236OC

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Article

Shared and Distinct Genomics of Chronic Thromboembolic Pulmonary Hypertension and Pulmonary Embolism.

American journal of respiratory and critical care medicine - 15 Jun 2024

Liley James, Newnham Michael, Bleda Marta, Bunclark Katherine, Auger William, Barbera Joan Albert, Bogaard Harm, Delcroix Marion, Fernandes Timothy M, Howard Luke, Jenkins David, Lang Irene, Mayer Eckhard, Rhodes Chris, Simpson Michael, Southgate Laura, Trembath Richard, Wharton John, Wilkins Martin R, Gräf Stefan, Morrell Nicholas, Zaba Joanna Pepke, Toshner Mark

Abstract excerpt

Rationale: Chronic thromboembolic pulmonary hypertension involves the formation and nonresolution of thrombus, dysregulated inflammation, angiogenesis, and the development of a small-vessel vasculopathy. Objectives: We aimed to establish the genetic basis of chronic thromboembolic pulmonary hypertension to gain insight into its pathophysiological contributors. Methods: We conducted a genome-wide association study...

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Identifiers

PMID: 38470220
DOI: 10.1164/rccm.202307-1236OC
PMCID: PMC11208965

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