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Article

Multi-phenotype analyses of hemostatic traits with cardiovascular events reveal novel genetic associations.

Journal of thrombosis and haemostasis : JTH - 1 Jun 2022

Temprano-Sagrera Gerard, Sitlani Colleen M, Bone William P, Martin-Bornez Miguel, Voight Benjamin F, Morrison Alanna C, Damrauer Scott M, de Vries Paul S, Smith Nicholas L, Sabater-Lleal Maria

Abstract excerpt

BACKGROUND: Multi-phenotype analysis of genetically correlated phenotypes can increase the statistical power to detect loci associated with multiple traits, leading to the discovery of novel loci. This is the first study to date to comprehensively analyze the shared genetic effects within different hemostatic traits, and between these and their associated disease outcomes. OBJECTIVES: To discover novel genetic...

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Identifiers

PMID: 35285134
DOI: 10.1111/jth.15698
PMCID: PMC9314075

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