Article
Imputation-based analysis of association studies: candidate regions and quantitative traits.
PLoS genetics - 1 Jul 2007
Servin Bertrand, Stephens Matthew
Abstract excerpt
We introduce a new framework for the analysis of association studies, designed to allow untyped variants to be more effectively and directly tested for association with a phenotype. The idea is to combine knowledge on patterns of correlation among SNPs (e.g., from the International HapMap project or resequencing data in a candidate region of interest) with genotype data at tag SNPs collected on a phenotyped study...
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