Article
To identify associations with rare variants, just WHaIT: Weighted haplotype and imputation-based tests.
American journal of human genetics - 12 Nov 2010
Li Yun, Byrnes Andrea E, Li Mingyao
Abstract excerpt
Empirical evidences suggest that both common and rare variants contribute to complex disease etiology. Although the effects of common variants have been thoroughly assessed in recent genome-wide association studies (GWAS), our knowledge of the impact of rare variants on complex diseases remains limited. A number of methods have been proposed to test for rare variant association in sequencing-based studies, a...
Topics
- Diabetes Mellitus, Type 1
- Genetic Predisposition to Disease
- Genetic Techniques
- Genetic Variation
- Genome-Wide Association Study
- Haplotypes
- Humans
- Models, Statistical
- Sequence Analysis, DNA