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Article

A flexible approach for the analysis of rare variants allowing for a mixture of effects on binary or quantitative traits.

PLoS genetics - 1 Jan 2013

Clarke Geraldine M, Rivas Manuel A, Morris Andrew P

Abstract excerpt

Multiple rare variants either within or across genes have been hypothesised to collectively influence complex human traits. The increasing availability of high throughput sequencing technologies offers the opportunity to study the effect of rare variants on these traits. However, appropriate and computationally efficient analytical methods are required to account for collections of rare variants that display a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23966874
DOI: 10.1371/journal.pgen.1003694
PMCID: PMC3744430

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