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Article

The Role of TCF7L2 in Type 2 Diabetes.

Diabetes - 1 Jun 2021

Del Bosque-Plata Laura, Martínez-Martínez Eduardo, Espinoza-Camacho Miguel Ángel, Gragnoli Claudia

Abstract excerpt

TCF7L2 is the most potent locus for type 2 diabetes (T2D) risk and the first locus to have been robustly reported by genomic linkage studies. TCF7L2 is a transcription factor that forms a basic part of the Wnt signaling pathway. This gene has highly conserved sequence regions that correspond to functional domains. The association of TCF7L2 with T2D is one of the most powerful genetically discovered in studies of...

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Share to Adipogenesis
Share to Diabetes Mellitus, Type 2
Share to Genetic Association Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Predisposition to Disease

Share to Genotype

Share to Polymorphism, Single Nucleotide

Share to Transcription Factor 7-Like 2 Protein

Share to Wnt Signaling Pathway

Source

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Identifiers

PMID: 34016596
DOI: 10.2337/db20-0573
PMCID: PMC8275893

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