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Article

Proper recruitment of gamma-tubulin and D-TACC/Msps to embryonic Drosophila centrosomes requires Centrosomin Motif 1.

Molecular biology of the cell - 1 Oct 2007

Zhang Jiuli, Megraw Timothy L

Abstract excerpt

Centrosomes are microtubule-organizing centers and play a dominant role in assembly of the microtubule spindle apparatus at mitosis. Although the individual binding steps in centrosome maturation are largely unknown, Centrosomin (Cnn) is an essential mitotic centrosome component required for assembly of all other known pericentriolar matrix (PCM) proteins to achieve microtubule-organizing activity at mitosis in...

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Identifiers

PMID: 17671162
DOI: 10.1091/mbc.e07-05-0474
PMCID: PMC1995719

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Proper recruitment of gamma-tubulin and D-TACC/Msps to embryonic Drosophila centrosomes requires Centrosomin Motif 1.PMID 17671162Read ↗

The centrosomin protein is required for centrosome assembly and function during cleavage in Drosophila.Semantic proximity Read ↗

Mutations in centrosomin reveal requirements for centrosomal function during early Drosophila embryogenesis.Semantic proximity Read ↗

Aurora A activates D-TACC-Msps complexes exclusively at centrosomes to stabilize centrosomal microtubules.Semantic proximity Read ↗

Centrocortin cooperates with centrosomin to organize Drosophila embryonic cleavage furrows.Semantic proximity Read ↗

Functional role of centrosomes in spindle assembly and organization.Semantic proximity Read ↗

Emerging roles of centrosome cohesionSemantic proximity Read ↗

A Unique Set of Centrosome Proteins Requires Pericentrin for Spindle-Pole Localization and Spindle OrientationSemantic proximity Read ↗

Auto-inhibition of Cnn binding to γ-TuRCs prevents ectopic microtubule nucleation and cell division defectsSemantic proximity Read ↗

The Drosophila pericentrin-like protein is essential for cilia/flagella function, but appears to be dispensable for mitosis.Semantic proximity Read ↗

The centrosome cycleSemantic proximity Read ↗

Drosophila Aurora A kinase is required to localize D-TACC to centrosomes and to regulate astral microtubules.Semantic proximity Read ↗

Drosophila melanogaster gamma-TuRC is dispensable for targeting gamma-tubulin to the centrosome and microtubule nucleation.Semantic proximity Read ↗

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