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Article

A novel TBX20 loss‑of‑function mutation contributes to adult‑onset dilated cardiomyopathy or congenital atrial septal defect.

Molecular medicine reports - 1 Oct 2016

Zhou Yi-Meng, Dai Xiao-Yong, Huang Ri-Tai, Xue Song, Xu Ying-Jia, Qiu Xing-Biao, Yang Yi-Qing

Abstract excerpt

Dilated cardiomyopathy (DCM) is the most prevalent form of primary cardiomyopathy in humans and is a leading cause of heart failure and sudden cardiac death. Genetic abnormalities have been demonstrated to be a major contributor to the development of DCM. However, DCM is a genetically heterogeneous disease, and the genetic basis underlying DCM in a significant proportion of patients remains unclear. In the...

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Topics

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Share to Cardiomyopathy, Dilated
Share to GATA4 Transcription Factor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Heart Septal Defects, Atrial

Share to Heterozygote

Share to Homeobox Protein Nkx-2.5

Share to Mutation, Missense

Share to Point Mutation

Share to T-Box Domain Proteins

Source

Identifiers

PMID: 27510170
DOI: 10.3892/mmr.2016.5609

Genes

TBX20

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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