Article
Point mutations in c-Myc uncouple neoplastic transformation from multiple other phenotypes in rat fibroblasts.
PloS one - 28 Oct 2010
Graves J Anthony, Rothermund Kristi, Wang Tao, Qian Wei, Van Houten Bennett, Prochownik Edward V
Abstract excerpt
Deregulation of c-Myc (Myc) occurs in many cancers. In addition to transforming various cell types, Myc also influences additional transformation-associated cellular phenotypes including proliferation, survival, genomic instability, reactive oxygen species production, and metabolism. Although Myc is wild type in most cancers (wtMyc), it occasionally acquires point mutations in certain lymphomas. Some of these...
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