Article
Human trk oncogenes activated by point mutation, in-frame deletion, and duplication of the tyrosine kinase domain.
Molecular and cellular biology - 1 Aug 1990
Coulier F, Kumar R, Ernst M, Klein R, Martin-Zanca D, Barbacid M
Abstract excerpt
Malignant activation of the human trk proto-oncogene, a member of the tyrosine protein kinase receptor family, has been implicated in the development of certain human cancers, including colon and thyroid papillary carcinomas. trk oncogenes have also been identified in cultured cells transfected w...
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- Cell Transformation, Neoplastic
- Cells, Cultured
- Chromosome Deletion
- Cloning, Molecular
- Gene Expression Regulation
- Humans
- Mice
- Molecular Sequence Data
- Mutation
- Oligonucleotide Probes
- Oncogenes
- Plasmids
- Poly A
- Protein-Tyrosine Kinases
- Proto-Oncogene Mas