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Article

Human trk oncogenes activated by point mutation, in-frame deletion, and duplication of the tyrosine kinase domain.

Molecular and cellular biology - 1 Aug 1990

Coulier F, Kumar R, Ernst M, Klein R, Martin-Zanca D, Barbacid M

Abstract excerpt

Malignant activation of the human trk proto-oncogene, a member of the tyrosine protein kinase receptor family, has been implicated in the development of certain human cancers, including colon and thyroid papillary carcinomas. trk oncogenes have also been identified in cultured cells transfected with various DNAs. In this study, we report the characterization of three in vitro-generated trk oncogenes, trk2, trk4,...

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Identifiers

PMID: 1695324
DOI: 10.1128/mcb.10.8.4202-4210.1990
PMCID: PMC360953

Genes

AGT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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