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Article

A survey of hypothalamic phenotypes identifies molecular and behavioral consequences of MYT1L haploinsufficiency in male and female mice.

Hormones and behavior - 1 Aug 2025

Maloney Susan E, McCullough Katherine B, Chaturvedi Sneha M, Selmanovic Din, Chase Rebecca, Chen Jiayang, Wu Shanyun, Granadillo Jorge L, Kroll Kristen L, Dougherty Joseph D

Abstract excerpt

The transcription factor MYT1L supports proper neuronal differentiation and maturation during brain development. MYT1L haploinsufficiency results in a neurodevelopmental disorder characterized by intellectual disability, developmental delay, autism, behavioral disruptions, aggression, obesity and epilepsy. While MYT1L is expressed throughout the brain, how it supports proper neuronal function in distinct regions...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 40729938
DOI: 10.1016/j.yhbeh.2025.105796
PMCID: PMC12893770

Genes

MYT1L

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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