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Article

Sphingosylphosphocholine effects on cultured astrocytes reveal mechanisms potentially involved in neurotoxicity in Niemann-Pick type A disease.

The European journal of neuroscience - 1 Aug 2007

Chiulli Nino, Codazzi Franca, Di Cesare Alessandra, Gravaghi Claudia, Zacchetti Daniele, Grohovaz Fabio

Abstract excerpt

Niemann-Pick type A is a disease characterized by the absence of a functional SMPD1 (acidic sphingomyelinase) gene and the abnormal accumulation of sphingomyelin. Under these conditions, also sphingosylphosphocholine (SPC, a sphingomyelin metabolite) accumulates in various tissues, including the brain, where it might act as a toxic stimulus, contributing to the appearance of the neurological symptoms. We studied...

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Source

Identifiers

PMID: 17666077
DOI: 10.1111/j.1460-9568.2007.05732.x

Genes

SMPD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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