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Article

Sphingosine 1-phosphate induces the production of glial cell line-derived neurotrophic factor and cellular proliferation in astrocytes.

Glia - 15 Jan 2003

Yamagata Kazuo, Tagami Motoki, Torii Yasuyoshi, Takenaga Fumio, Tsumagari Shigehisa, Itoh Shingo, Yamori Yukio, Nara Yasuo

Abstract excerpt

Sphingosine 1-phosphate (S1P) is a platelet-derived bioactive sphingolipid that evokes a variety of biological responses. To understand the role of S1P in the central nervous system, we have examined the effect of S1P on the production of glial cell line-derived neurotrophic factor (GDNF) and growth regulation of cortical astrocytes from rat embryo. Moreover, we examined the possibility that the expression of...

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PMID: 12509810
DOI: 10.1002/glia.10180

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GDNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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