Article
Evidence against involvement of the acid lysosomal sphingomyelinase in the tumor-necrosis-factor- and interleukin-1-induced sphingomyelin cycle and cell proliferation in human fibroblasts.
The Biochemical journal - 15 Oct 1994
Andrieu N, Salvayre R, Levade T
Abstract excerpt
The hydrolysis of sphingomyelin (SPM) has been reported to mediate a number of responses to extracellular agents, including cytokines. The so-called SPM cycle may result from the activation of different types of sphingomyelinases (SPMases). We investigated the hypothetical contribution of acid ly...
Topics
- Cell Division
- Cell Line
- Enzyme Activation
- Fibroblasts
- Humans
- Hydrolysis
- Interleukin-1
- Interleukin-1beta
- Lysosomes
- Mitogens
- Mucolipidoses
- Mutation
- Niemann-Pick Diseases
- Peptide Fragments
- Recombinant Proteins
- Signal Transduction
- Skin
- Sphingomyelin Phosphodiesterase