Article

Effects of curcumin nanoformulations on cellular function in Niemann-Pick disease type C astrocytes

2017-05-09

Abstract excerpt

Niemann-Pick disease type C1 (NPC disease) is a neurodegenerative multi-lipid lysosomal storage disease caused by mutations in the NPC1 gene presenting with reduced lysosomal Ca 2+ signalling and inhibited late endosome-lysosome transport. Elevating cytosolic Ca 2+ levels in NPC cells has been shown to reduce lysosomal lipid storage. Treating Npc1 -/- mice with the Ca 2+ modulator curcumin led to reduced lip...

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Literature Corpus work: 321ca2f8-d9e6-5c51-a630-2a364cd0d04b
DOI: 10.1101/135830

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