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Article

Role of astrocyte purinergic signaling in epilepsy

9 Nov 2019

Abstract excerpt

Epilepsy is characterized by unpredictable recurrent seizures resulting from hypersynchronous discharges from neuron assemblies. Increasing evidence indicates that aberrant astrocyte signaling to neurons plays an important role in driving the network hyperexcitability. Purinergic signaling is central in neuron-glia and glia-glia interactions and dysfunctions in communication pathways involving purinergic...

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PMID: 31705600
DOI: 10.1002/glia.23747

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