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Article

The stimulation of adenosine A2A receptors ameliorates the pathological phenotype of fibroblasts from Niemann-Pick type C patients.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 25 Sept 2013

Visentin Sergio, De Nuccio Chiara, Bernardo Antonietta, Pepponi Rita, Ferrante Antonella, Minghetti Luisa, Popoli Patrizia

Abstract excerpt

Niemann-Pick type C1 (NPC1) disease is a rare neurovisceral disorder characterized by intracellular accumulation of unesterified cholesterol, sphingolipids, and other lipids in the lysosomal compartment. A deregulation of lysosomal calcium has been identified as one of the earliest steps of the degenerative process. Since adenosine A2A receptors (A2ARs) control lysosome trafficking and pH, which closely regulates...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24068806
DOI: 10.1523/JNEUROSCI.0558-13.2013
PMCID: PMC6618463

Genes

NPC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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