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Unique p53 and epidermal growth factor receptor gene mutation status in 46 pulmonary lymphoepithelioma-like carcinomas.

Cancer science - 1 Jan 2011

Chang Yih-Leong, Wu Chen-Tu, Shih Jin-Yuan, Lee Yung-Chie

Abstract excerpt

p53 and epidermal growth factor receptor (EGFR) are common genes involved in the pathogenesis of lung cancer, but their roles in lymphoepithelioma-like carcinomas (LELC) are unclear. In this study, we investigate the roles of p53 and EGFR in LELC carcinogenesis. Forty-six pulmonary LELCs were identified to evaluate p53 and EGFR aberrations. p53 mutations were identified in three patients, which all occurred in...

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Carcinoma, Non-Small-Cell Lung
ErbB Receptors
EGFR gene

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PMID: 21070477
DOI: 10.1111/j.1349-7006.2010.01768.x

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