Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mutational analysis of pulmonary large cell neuroendocrine carcinoma: APC gene mutations identify a good prognostic factor.

Lung cancer (Amsterdam, Netherlands) - 1 Jun 2024

Li Mengqian, Zhang Ying, Zhou Ping, Miao Yuqing, Li Shuang, Jiang Lili

Abstract excerpt

Pulmonary large cell neuroendocrine carcinoma (LCNEC) is a highly aggressive neoplasm with biological heterogeneity. Mutations in multiple genes have been identified in LCNEC. However, associations between gene alterations, histopathological characteristics, and prognosis remain ambiguous. Here, we investigated the clinicopathologic, immunohistochemical, and genomic characteristics of 19 patients with LCNEC and 9...

Topics

Humans
Male
Female
Carcinoma, Neuroendocrine
Mutation
Middle Aged
Prognosis
Lung Neoplasms
Aged
Carcinoma, Large Cell
DNA Mutational Analysis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Adult

Biomarkers, Tumor

Adenomatous Polyposis Coli Protein

Aged, 80 and over

Source

Identifiers

PMID: 38795461
DOI: 10.1016/j.lungcan.2024.107825

Genes

APC
RB1
MCL1
TP53

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mutational analysis of pulmonary large cell neuroendocrine carcinoma: APC gene mutations identify a good prognostic factor.PMID 38795461Read ↗

Molecular Pathology of Pulmonary Large Cell Neuroendocrine Carcinoma: Novel Concepts and TreatmentsSemantic proximity Read ↗

Gene Expression Profiling of Lung Atypical Carcinoids and Large Cell Neuroendocrine Carcinomas Identifies Three Transcriptomic Subtypes with Specific Genomic AlterationsSemantic proximity Read ↗

Next-Generation Sequencing of Pulmonary Large Cell Neuroendocrine Carcinoma Reveals Small Cell Carcinoma-like and Non-Small Cell Carcinoma-like Subsets.Semantic proximity Read ↗

Mutational analysis of pulmonary tumours with neuroendocrine features using targeted massive parallel sequencing: a comparison of a neglected tumour group.Semantic proximity Read ↗

The Unmet Diagnostic and Treatment Needs in Large Cell Neuroendocrine Carcinoma of the LungSemantic proximity Read ↗

Genomic Profiling of Large-Cell Neuroendocrine Carcinoma of the Lung.Semantic proximity Read ↗

Molecular Subtypes of Pulmonary Large-cell Neuroendocrine Carcinoma Predict Chemotherapy Treatment Outcome.Semantic proximity Read ↗

Next-Generation Sequencing of a Cohort of Pulmonary Large Cell Carcinomas Reclassified by World Health Organization 2015 Criteria.Semantic proximity Read ↗

ALK-rearrangement neuroendocrine carcinoma of the lung: a comprehensive study of a rare case series and review of literatureSemantic proximity Read ↗

Beyond Traditional Morphological Characterization of Lung Neuroendocrine Neoplasms: In Silico Study of Next-Generation Sequencing Mutations Analysis across the Four World Health Organization Defined GroupsSemantic proximity Read ↗

Identification of Actionable Gene Variants in Pulmonary Large-Cell Neuroendocrine Carcinoma: A Real-World Analysis of a Polish Cohort.Semantic proximity Read ↗

Prevalence of TP-53/Rb-1 Co-Mutation in Large Cell Neuroendocrine CarcinomaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.