Article
p53 immunostaining positivity is associated with reduced survival and is imperfectly correlated with gene mutations in resected non-small cell lung cancer. A preliminary report of LCSG 871.
Chest - 1 Dec 1994
Carbone D P, Mitsudomi T, Chiba I, Piantadosi S, Rusch V, Nowak J A, McIntire D, Slamon D, Gazdar A, Minna J
Abstract excerpt
We investigated the correlation of p53 abnormalities with survival in 85 patients with non-small cell lung cancer (NSCLC) who had undergone resection with curative intent as part of Lung Cancer Study Group (LCSG) 871. Our previous studies showed that only a subset of p53 mutations in lung cancers result in overexpression. In addition, protein overexpression has been described in the absence of mutation....
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