Article
Correlation of TP53 Mutations With p53 Expression and Ki-67 Index in Pulmonary Large Cell Neuroendocrine Carcinomas.
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica - 1 Apr 2026
Stampe Martin, Smidt Jonas, Melchior Linea, Grauslund Morten, Federspiel Birgitte, Santoni-Rugiu Eric, Jensen Thomas Hartvig Lindkær
Abstract excerpt
This study explores the locations and distribution of mutations in the exons of the TP53 gene in pulmonary large cell neuroendocrine carcinomas (LCNEC) and the corresponding expression of p53 as well as the Ki-67 proliferation index. Real-world data from routine diagnostics were collected retrospectively from 149 consecutive cases of pulmonary LCNEC. They included next-generation sequencing (NGS) of the TP53 gene...
Topics
- Humans
- Ki-67 Antigen
- Tumor Suppressor Protein p53
- Carcinoma, Neuroendocrine
- Mutation
- Lung Neoplasms
- Immunohistochemistry
- Female
- Carcinoma, Large Cell
- Retrospective Studies