Article
Association of genetic polymorphisms of endothelin-converting enzyme-1 gene with hypertension in a Japanese population and rare missense mutation in preproendothelin-1 in Japanese hypertensives.
Hypertension research : official journal of the Japanese Society of Hypertension - 1 Jun 2007
Banno Mariko, Hanada Hironori, Kamide Kei, Kokubo Yoshihiro, Kada Akiko, Yang Jin, Tanaka Chihiro, Takiuchi Shin, Horio Takeshi, Matayoshi Tetsutaro, Yasuda Hisayo, Nagura Junko, Tomoike Hitonobu, Kawano Yuhei, Miyata Toshiyuki
Abstract excerpt
Endothelin-1 (EDN1), a 21-amino acid peptide, is a potent vasoconstrictor with various pharmacological responses. EDN1 is synthesized from a 212-amino acid precursor protein, preproEDN1, through multiple proteolytic steps. Endothelin-converting enzyme (ECE) cleaves a Trp73-Val74 peptide bond in big-EDN1 to give rise to mature EDN1. In this study, we examined the possible association of genetic variations in ECE1...
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