Article
Association of single nucleotide polymorphisms in the 3'UTR of ERAP1 gene with essential hypertension in the Northeastern Han Chinese.
Gene - 15 Apr 2015
Yang Sibao, Liu Xueyan, Gao Yongjian, Ding Mei, Li Bing, Sun Huan, He Yuquan, Yang Ping
Abstract excerpt
Endoplasmic reticulum aminopeptidase 1 (ERAP1) may be involved in blood pressure regulation by inactivation of angiotensin II and generation of bradykinin. Our previous study with cDNA microarray indicated that the expression of ERAP1 is down-regulated in essential hypertension (EH) patients. Since the 3'untranslated region (3'UTR) is known to play an important role in the post-transcriptional regulation by...
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