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Article

Association of Endothelin-Converting Enzyme and Endothelin-1 Gene Polymorphisms with Essential Hypertension in Malay Ethnics.

Genetics research - 1 Jan 2022

Salim Elnaz, Ramachandran Vasudevan, Ansari Neda, Ismail Patimah, Mohamed Mohd Hazmi, Mohamad Nur Afiqah, Inche Mat Liyana Najwa

Abstract excerpt

Objectives: Endothelin-1 (ET-1), the most potent endogenous vasoconstrictor, generated by enzymatic cleavage catalyzed by an endothelin-converting enzyme (ECE), plays a significant role in the regulation of hypertension. Methods: This study investigates the effect of endothelin-1 (Lys198Asn/rs5370) and ECE (rs212526 C/T) gene polymorphisms with essential hypertension (EH) among Malay ethnics. To determine the...

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Identifiers

PMID: 35645613
DOI: 10.1155/2022/9129960
PMCID: PMC9126669

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