Article
Emilin1 gene and essential hypertension: a two-stage association study in northern Han Chinese population.
BMC medical genetics - 18 Nov 2009
Shen Chong, Lu Xiangfeng, Li Yun, Zhao Qi, Liu Xiaoli, Hou Liping, Wang Laiyuan, Chen Shufeng, Huang Jianfeng, Gu Dongfeng
Abstract excerpt
BACKGROUND: Elastogenesis of elastic extracellular matrix (ECM) which was recognized as a major component of blood vessels has been believed for a long time to play only a passive role in the dynamic vascular changes of typical hypertension. Emilin1 gene participated in the transcription of ECM's formation and was recognized to modulate links TGF-beta maturation to blood pressure homeostasis in animal study....
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