Article
Impact of endothelin-1 Lys198Asn polymorphism on coronary artery disease and endorgan damage in hypertensives.
Coronary artery disease - 1 Nov 2008
Popov Aron Frederik, Schulz Egbert Godehard, Hinz Jose, Schmitto Jan Dieter, Seipelt Ralf, Koziolek Michael Johann, Rosenberger Albert, Schoendube Friedrich Albert, Müller Gerhard Anton
Abstract excerpt
OBJECTIVE: Endothelin is the most potent endogenous vasoconstrictor and is involved in several vascular disorders such as arterial hypertension. Its intense interaction with other vasoactive hormone systems revealed the consideration about the endothelin gene as an interesting candidate for influencing the development of essential hypertension and hypertensive endorgan damage. The purpose of this study was to...
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