Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Complement activation and antibody binding by pneumolysin via a region of the toxin homologous to a human acute‐phase protein

1 Aug 1991

Abstract excerpt

Pneumolysin, a membrane-damaging toxin, is known to activate the classical complement pathway. We have shown that 1 microgram ml-1 of pneumolysin can activate complement, which is a much lower level than observed previously. We have identified two distinct regions of pneumolysin which show homology with a contiguous sequence within acute-phase proteins, including human C-reactive protein (CRP). Site-directed...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Blood groups and transfusion
Share to Complement system in diseases
Share to Erythrocyte Function and Pathophysiology

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 1766369
DOI: 10.1111/j.1365-2958.1991.tb00812.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Complement activation and antibody binding by pneumolysin via a region of the toxin homologous to a human acute‐phase proteinPMID 1766369Read ↗

Pneumolysin: A Double-Edged Sword During the Host-Pathogen InteractionSemantic proximity Read ↗

The molecular mechanism of pneumolysin, a virulence factor from Streptococcus pneumoniae.Semantic proximity Read ↗

Differential Interaction of the Staphylococcal Toxins Panton–Valentine Leukocidin and γ-Hemolysin CB with Human C5a ReceptorsSemantic proximity Read ↗

Role of the property of C-reactive protein to activate the classical pathway of complement in protecting mice from pneumococcal infection.Semantic proximity Read ↗

Site-directed mutagenesis of the hole-forming toxin aerolysin: studies on the roles of histidines in receptor binding and oligomerization of the monomer.Semantic proximity Read ↗

Analysis of binding sites in human C-reactive protein for Fc{gamma}RI, Fc{gamma}RIIA, and C1q by site-directed mutagenesis.Semantic proximity Read ↗

Purification of recombinant C-reactive protein mutants.Semantic proximity Read ↗

Comparative virulence of Streptococcus pneumoniae strains with insertion-duplication, point, and deletion mutations in the pneumolysin gene.Semantic proximity Read ↗

Pneumococcal Pneumolysin Induces DNA Damage and Cell Cycle ArrestSemantic proximity Read ↗

Probing the C1q-binding site on human C-reactive protein by site-directed mutagenesis.Semantic proximity Read ↗

Human C-reactive protein protects mice from Streptococcus pneumoniae infection without binding to pneumococcal C-polysaccharide.Semantic proximity Read ↗

Hic, a novel surface protein of Streptococcus pneumoniae that interferes with complement function.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.