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Article

Probing the C1q-binding site on human C-reactive protein by site-directed mutagenesis.

1 Jun 1994

Abstract excerpt

We have used oligonucleotide-directed site-specific mutagenesis to investigate structural determinants of the C1q-binding site of C-reactive protein (CRP). Eleven mutant rCRP cDNAs, D112N; D112A; D112K; D112E; K114T; K114A; K114E; K114R; R116L; D112N, K114T; and D112N, R116L were constructed and expressed in COS cells. Wild-type (wt) and all mutant rCRPs bound to phosphocholine-substituted BSA and also to...

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PMID: 8189060
DOI: 10.4049/jimmunol.152.11.5404

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