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Article

The molecular mechanism of pneumolysin, a virulence factor from Streptococcus pneumoniae.

Journal of molecular biology - 27 Nov 1998

Rossjohn J, Gilbert R J, Crane D, Morgan P J, Mitchell T J, Rowe A J, Andrew P W, Paton J C, Tweten R K, Parker M W

Abstract excerpt

Pneumolysin, a member of the thiol-activated cytolysin family of toxins, is a virulence factor from the Gram-positive bacterium Streptococcus pneumoniae. The toxin forms large oligomeric pores in cholesterol-containing membranes of eukaryotic cells. A plethora of biochemical and mutagenesis data have been published on pneumolysin, since its initial characterization in the 1930s. Here we present an homology model...

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Identifiers

PMID: 9813129
DOI: 10.1006/jmbi.1998.2167

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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