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Article

Analysis of binding sites in human C-reactive protein for Fc{gamma}RI, Fc{gamma}RIIA, and C1q by site-directed mutagenesis.

The Journal of biological chemistry - 1 Jul 2005

Bang Ranhy, Marnell Lorraine, Mold Carolyn, Stein Mary-Pat, Clos Kevin T Du, Chivington-Buck Corinn, Clos Terry W Du

Abstract excerpt

Human C-reactive protein (CRP) is a classical, acute phase serum protein synthesized by the liver in response to infection, inflammation, or trauma. CRP binds to microbial antigens and damaged cells, opsonizes particles for phagocytosis and regulates the inflammatory response by the induction of cytokine synthesis. These activities of CRP depend on its ability to activate complement and to bind to Fcgamma...

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Identifiers

PMID: 15878871
DOI: 10.1074/jbc.M504782200

Genes

CRP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Analysis of binding sites in human C-reactive protein for Fc{gamma}RI, Fc{gamma}RIIA, and C1q by site-directed mutagenesis.PMID 15878871Read ↗

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