Article
Comparative virulence of Streptococcus pneumoniae strains with insertion-duplication, point, and deletion mutations in the pneumolysin gene.
Infection and immunity - 1 Feb 1999
Berry A M, Ogunniyi A D, Miller D C, Paton J C
Abstract excerpt
Pneumolysin is a 471-amino-acid toxin produced by Streptococcus pneumoniae which has both cytolytic and complement activation properties. We have constructed a derivative of the type 2 S. pneumoniae strain D39 in which the portion of the pneumolysin gene encoding amino acids 55 to 437 has been de...
Topics
- Animals
- Bacterial Proteins
- Gene Deletion
- Gene Duplication
- Genes, Bacterial
- Mice
- Mice, Inbred BALB C
- Mutagenesis, Insertional
- Mutation
- Pneumococcal Infections
- Point Mutation
- Streptococcus pneumoniae
- Streptolysins
- Virulence