Article
Structural basis for activation of the receptor tyrosine kinase KIT by stem cell factor.
Cell - 27 Jul 2007
Yuzawa Satoru, Opatowsky Yarden, Zhang Zhongtao, Mandiyan Valsan, Lax Irit, Schlessinger Joseph
Abstract excerpt
Stem Cell Factor (SCF) initiates its multiple cellular responses by binding to the ectodomain of KIT, resulting in tyrosine kinase activation. We describe the crystal structure of the entire ectodomain of KIT before and after SCF stimulation. The structures show that KIT dimerization is driven by SCF binding whose sole role is to bring two KIT molecules together. Receptor dimerization is followed by...
Topics
- Amino Acid Sequence
- Binding Sites
- Crystallography, X-Ray
- Dimerization
- Disease
- Enzyme Activation
- Humans
- Ligands
- Models, Molecular
- Molecular Sequence Data
- Mutation