The fourth immunoglobulin domain of the stem cell factor receptor couples ligand binding to signal transduction.

doi:10.1016/0092-8674(95)90455-7

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Article

The fourth immunoglobulin domain of the stem cell factor receptor couples ligand binding to signal transduction.

Cell - 13 Jan 1995

Blechman J M, Lev S, Barg J, Eisenstein M, Vaks B, Vogel Z, Givol D, Yarden Y

Abstract excerpt

Receptor dimerization is ubiquitous to the action of all receptor tyrosine kinases, and in the case of dimeric ligands, such as the stem cell factor (SCF), it was attributed to ligand bivalency. However, by using a dimerization-inhibitory monoclonal antibody to the SCF receptor, we confined a put...

Topics

Animals
Antibodies, Monoclonal
Base Sequence
Binding Sites
Cells, Cultured
Enzyme Activation
Epitope Mapping
Hematopoietic Cell Growth Factors
Humans
Ligands
Mice
Models, Molecular
Molecular Sequence Data
Mutation
Proto-Oncogene Proteins
Proto-Oncogene Proteins c-kit
Receptor Protein-Tyrosine Kinases
Receptors, Colony-Stimulating Factor

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Identifiers

PMID: 7529140
DOI: 10.1016/0092-8674(95)90455-7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7529140-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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