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Article

Soluble c-kit proteins and antireceptor monoclonal antibodies confine the binding site of the stem cell factor.

The Journal of biological chemistry - 25 Feb 1993

Blechman J M, Lev S, Brizzi M F, Leitner O, Pegoraro L, Givol D, Yarden Y

Abstract excerpt

The binding of the stem cell factor (SCF) to the c-kit-encoded receptor tyrosine kinase stimulates a variety of biochemical responses that culminate in cellular proliferation, migration, or survival. The extracellular domain of p145kit consists of five immunoglobulin-like domains. To confine the ligand binding site to this portion of the receptor we generated a panel of murine monoclonal antibodies (mAbs) to the...

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PMID: 7680037

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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