Article
Soluble c-kit proteins and antireceptor monoclonal antibodies confine the binding site of the stem cell factor.
The Journal of biological chemistry - 25 Feb 1993
Blechman J M, Lev S, Brizzi M F, Leitner O, Pegoraro L, Givol D, Yarden Y
Abstract excerpt
The binding of the stem cell factor (SCF) to the c-kit-encoded receptor tyrosine kinase stimulates a variety of biochemical responses that culminate in cellular proliferation, migration, or survival. The extracellular domain of p145kit consists of five immunoglobulin-like domains. To confine the...
Topics
- Animals
- Antibodies, Monoclonal
- Binding Sites
- CHO Cells
- Cricetinae
- Cross-Linking Reagents
- Hematopoietic Cell Growth Factors
- Mutation
- Protein-Tyrosine Kinases
- Proto-Oncogene Proteins
- Proto-Oncogene Proteins c-kit
- Receptors, Colony-Stimulating Factor
- Recombinant Proteins
- Sequence Deletion
- Solubility
- Stem Cell Factor