Article
Structural basis for KIT receptor tyrosine kinase inhibition by antibodies targeting the D4 membrane-proximal region.
Proceedings of the National Academy of Sciences of the United States of America - 29 Oct 2013
Reshetnyak Andrey V, Nelson Bryce, Shi Xiarong, Boggon Titus J, Pavlenco Alevtina, Mandel-Bausch Elizabeth M, Tome Francisco, Suzuki Yoshihisa, Sidhu Sachdev S, Lax Irit, Schlessinger Joseph
Abstract excerpt
Somatic oncogenic mutations in the receptor tyrosine kinase KIT function as major drivers of gastrointestinal stromal tumors and a subset of acute myeloid leukemia, melanoma, and other cancers. Although treatment of these cancers with tyrosine kinase inhibitors shows dramatic responses and durable disease control, drug resistance followed by clinical progression of disease eventually occurs in virtually all...
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