Article
The role of the selenoprotein S (SELS) gene -105G>A promoter polymorphism in inflammatory bowel disease and regulation of SELS gene expression in intestinal inflammation.
Tissue antigens - 1 Sept 2007
Seiderer J, Dambacher J, Kühnlein B, Pfennig S, Konrad A, Török H-P, Haller D, Göke B, Ochsenkühn T, Lohse P, Brand S
Abstract excerpt
Recently, a -105G>A promoter polymorphism coding for selenoprotein S (SELS) has been shown to increase proinflammatory cytokine expression. We, therefore, analyzed SELS expression and potential phenotypic consequences of the -105G>A polymorphism in patients with inflammatory bowel disease (IBD). SELS mRNA was measured by quantitative polymerase chain reaction (PCR) in intestinal epithelial cells (IEC) after...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.