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Article

Polymorphisms in the selenoprotein S gene: lack of association with autoimmune inflammatory diseases.

BMC genomics - 14 Jul 2008

Martínez Alfonso, Santiago Jose Luis, Varadé Jezabel, Márquez Ana, Lamas José Ramón, Mendoza Juan Luis, de la Calle Hermenegildo, Díaz-Rubio Manuel, de la Concha Emilio G, Fernández-Gutiérrez Benjamín, Urcelay Elena

Abstract excerpt

BACKGROUND: Selenoprotein S (SelS) protects the functional integrity of the endoplasmic reticulum against the deleterious effects of metabolic stress. SEPS1/SelS polymorphisms have been involved in the increased release of pro-inflammatory cytokines interleukin (IL)-1beta, tumor necrosis factor (TNF)-alpha and IL-6 in macrophages. We aimed at investigating the role of the SEPS1 variants previously associated with...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 18625033
DOI: 10.1186/1471-2164-9-329
PMCID: PMC2491642

Genes

TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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