Article
A Gly15Arg mutation in the interleukin-10 gene reduces secretion of interleukin-10 in Crohn disease.
Scandinavian journal of gastroenterology - 1 Jun 2003
van der Linde K, Boor P P C, Sandkuijl L A, Meijssen M A C, Savelkoul H F J, Wilson J H P, de Rooij F W M
Abstract excerpt
BACKGROUND: Genetic susceptibility, probably involving cytokines and their receptors, plays an important role in inflammatory bowel disease (IBD). In this study we examine the potential role of the interleukin-10 (IL-10) gene as a susceptibility gene in IBD. METHODS: We studied 17 sib-pairs with...
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